Patent · US Active

LDLR negative packaging cell line for the production of VSV-G pseudotyped retroviral vector particles or virus particles thereof

US12286639B2 · kind B2 · utility

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24Claims

0Family size

Assignee

MILTENYI BIOTEC B.V. & CO. KG · DE

Inventors

Thomas Schaser · Rösrath, DE
Johann-Christoph Dettmann · Moitzfeld, DE
Martin Meyer · Kürten, DE
Ian Johnston · Rösrath, DE

Key dates

Filing date	Aug 28, 2019
Grant date	Apr 29, 2025
Priority date	—
Expiry date	Aug 25, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2810/6081
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention provides the use of a packaging cell line for the production of VSV-G pseudotyped retroviral vector particles or virus like particles thereof, wherein said packaging cell line is negative for Low-Density Lipoprotein Receptor (LDLR), optionally said packaging cell line stably expresses VSV-G. A method for producing said VSV-G pseudotyped retroviral vector particles or virus like particles thereof is disclosed as well as said particles obtained by said method.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.