Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US12290507B2 · kind B2 · utility
0Cited by
6References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 14, 2021 |
| Grant date | May 6, 2025 |
| Priority date | — |
| Expiry date | Sep 3, 2043 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R1, R2 and R3 which have the meanings given in the specification, and pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.