Implants including modified demineralized cortical bone fibers and methods of making same

US12295848B2 · kind B2 · utility

Assignee

• Musculoskeletal Transplant Foundation · US

Inventors

• Michele Christine McAllister · Freehold, US
• David Huabin Wang · Beavercreek, US
• Michelle Bubear · Newton, US
• Joed Canales · Harrison, US
• Amy Chang · Kaneohe, US
• Roman Shikhanovich · Edison, US
• Mark Spilker · Plainsboro, US
• Eric J. Semler · Piscataway, US

Key dates

• Filing date: Oct 14, 2022
• Grant date: May 13, 2025
• Expiry date: Oct 14, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/38
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.