Crystal form, preparation method, and application of 4'-substituted nucleoside
US12297224B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 21, 2019 |
| Grant date | May 13, 2025 |
| Priority date | — |
| Expiry date | Nov 7, 2041 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a crystal form, a preparation method and an application of a 4′-substituted nucleoside compound I having the following structure, including salts, prodrugs, and compositions thereof. Animal pharmacokinetic studies demonstrated that the effective drug concentrations of Compound Ia and Compound Ig in HIV target cells, peripheral blood mononuclear cells (PBMC), were effective in inhibiting HIV replication after 7 and 5 days, respectively. Therefore, Compound I can be used as a long-acting drug for preventing and treating AIDS. R is selected from ethynyl, azide, and cyano groups, X is selected from hydrogen and fluorine, and B is selected from B1 and B2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.