Synthetic system for tunable thresholding of protein signals
US12297230B2 · kind B2 · utility
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11References
20Claims
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Key dates
| Filing date | May 11, 2023 |
| Grant date | May 13, 2025 |
| Priority date | — |
| Expiry date | May 11, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/20
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein include methods, compositions, and kits suitable for use in thresholding of protein signals. There are provided, in some embodiments, synthetic protein circuits that respond to inputs only above or below a certain threshold concentration. In some embodiments, the threshold value itself is tunable. Methods of treating a disease or disorder characterized by aberrant signaling are provided in some embodiments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.