Multi-domain immunomodulatory proteins and methods of use thereof
US12297253B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 3, 2019 |
| Grant date | May 13, 2025 |
| Priority date | — |
| Expiry date | Mar 6, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are multi-domain immunomodulatory proteins, nucleic acids encoding such immunomodulatory proteins, cells engineered to express the immunomodulatory proteins and infectious agents containing nucleic acid encoding the immunomodulatory proteins. The immunomodulatory proteins bind both an inhibitory receptor and a receptor involved in activation signaling cascades in an immune cell, such as a T cell. The immunomodulatory proteins, engineered cells and infectious agents provide therapeutic utility for a variety of immunological diseases or conditions. Compositions and methods for making and using such proteins are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.