RGMC-selective inhibitors and use thereof

US12297262B2 · kind B2 · utility

Assignee

• Scholar Rock, Inc. · US

Inventors

• Samantha Nicholls · Arlington, US
• Adriana Donovan · Boston, US
• Meghan McDonald · London, GB
• Abhishek Datta · Boston, US
• Allan Capili · Somerville, US
• Kevin B. Dagbay · Watertown, US
• Lorena Lerner · Newton, US
• Leonard I. Zon · Wellesley, US
• Kevin Schutz · Lebanon, US
• John Bukowski · Lebanon, US
• Justin W. Jackson · Cambridge, US

Key dates

• Filing date: Oct 23, 2019
• Grant date: May 13, 2025
• Expiry date: Aug 1, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Selective inhibitors of repulsive guidance molecule C (RGMc), are described. Related methods, including methods for making, as well as therapeutic use of these inhibitors in the treatment of disorders, such as anemia, are also provided.