Peptide compounds targeting PD-1 receptor as well as preparation and applications thereof

US12297293B2 · kind B2 · utility

Assignee

• Nanjing University · CN

Inventors

• Gang Chen · Sammamish, US
• Long Zhao · Nanjing, CN
• Yayu Zhao · 安丰镇, CN
• Ying Chen · Los Angeles, US
• Hao Luo · Xiamen, CN
• Yonghui Zhang · Old Saybrook, US
• Jinhuan Wei · 安丰镇, CN

Key dates

• Filing date: Jun 1, 2022
• Grant date: May 13, 2025
• Expiry date: Jun 1, 2042

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A peptide compound targeting a PD-1 receptor includes: a compound 1, a compound 2, a compound 3, a compound 4 and a compound 5; wherein the compounds 1-5 comprise amino acid sequences identical to SEQ ID NO: 1-5, respectively. A method for preparing the peptide compound targeting the PD-1 receptor includes steps of: using a solid-phase synthesis method for coupling amino acids of the compounds 1-5 to a solid-phase resin sequentially according to peptide sequences, and obtaining a target compound after cleavage by a cutting reagent, freeze-drying, and preparative purification. A method for preparing analgesic drugs includes using the peptide compound targeting the PD-1 receptor. The compounds 1-5 are capable of binding to PD-1, and have significant inhibitory effects on inflammatory pain and visceral pain under intrathecal administration; they are simple to synthesize, easy to be purified, and conducive to large-scale synthesis.