Mammalian cell population and medicaments for cell therapies in canines and improved cell cultivation methods
US12297454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 17, 2023 |
| Grant date | May 13, 2025 |
| Priority date | — |
| Expiry date | Apr 17, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2509/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions of matter, including cell populations and medicaments, are provided that are derived from canine gingival fibroblasts and have cell phenotypes that occur in proportions not found in natural gum tissue, but rather, are preferentially are selected to express proteins favoring angiogenesis and anti-inflammatory effects, while reducing cell populations that promote tumorigenicity and/or formation of metalloproteinases that inhibit tissue regeneration. Methods of generating such compositions are provided that increase proliferation many-fold compared to previously known methods, and methods of using such compositions in a wide range of canine cell therapies are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.