Patent · US Active

Method for determining at least one quality parameter of an RNA sample

US12297489B2 · kind B2 · utility

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34Claims

0Family size

Assignee

CureVac Manufacturing GmbH · DE

Inventors

Stefan Heinz · Eppstein, DE
Tilmann ROOS · Aspenhausiedlung, DE

Key dates

Filing date	May 17, 2018
Grant date	May 13, 2025
Priority date	—
Expiry date	Sep 2, 2040

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q2600/166
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to a method for quality control analysis of an RNA sample comprising n different RNA molecule species using reverse transcription and a polymerase chain reaction (PCR) based assay, dPCR, preferably ddPCR, thereby determining at least one quality parameter. Moreover, the RNA molecules in the RNA sample may be in complexed form. In particular, the method is suitable for use in quality control during or following production of RNA samples for pharmaceutical use.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.