Non-aqueous chemotherapeutic suspensions for oral dosage

US12303504B2 · kind B2 · utility

Assignee

• ONCOSOL LIMITED · GB

Inventors

• Vijay Patel · Loughborough, GB
• Sandip P. Mehta · Ahmedabad, IN
• Manish Umrethia · Ahmedabad, IN
• Jayanta Kumar MANDAL · Ahmedabad, IN

Key dates

• Filing date: Sep 13, 2019
• Grant date: May 20, 2025
• Expiry date: Sep 22, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions comprising oil as a vehicle, a suspending agent, and a surfactant are disclosed to be used in conjunction with active pharmaceutical ingredients which are water soluble or insoluble, or which are sensitive to water but insoluble in oil. Such active pharmaceutical ingredients may include temozolomide, lenalidomide, Oxaliplatin, Cisplatin, Carboplatin, 5-fluorouracil, irinotecan, topotecan, cyclophosphamide, doxorubicin, vincristine, vinblastine, Melphalan, Chlorambucil, Dacarbazine, Daunorubicin, Epirubicin, Mitoxantrone, Etoposide, Teniposide, Azacitidine, Cytarabine, Gemcitabine, vinoralbine, Pemetrexed, a derivative thereof, or a combination thereof. The pharmaceutical compositions may be administered as an oral suspension. Other embodiments are directed towards methods of using and methods of making such formulations.