Formulation of contrast media and process of preparation thereof

US12303573B2 · kind B2 · utility

Assignees

• BAYER HEALTHCARE LLC · DE
• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Stephan Holzschuh · Haan, DE
• Thomas Frenzel · Berlin, DE
• Gregor Jost · Berlin, DE
• Jessica Lohrke · Berlin, DE
• Wolfgang Ebert · Krefeld, DE
• Thomas Brumby · Berlin, DE
• Wolfgang Halfbrodt · Berlin, DE

Key dates

• Filing date: Mar 26, 2024
• Grant date: May 20, 2025
• Expiry date: Mar 26, 2044

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/124
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to a liquid pharmaceutical formulation comprising a DO3A-derived tetra-chelate of formula (I), in which M is an ion of a paramagnetic metal, preferably a Gd3+ ion, and R1, R2, R3, R4 and R5 are as defined in the claims, in a pharmaceutical acceptable solvent. The present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.