Continuous post-treatment method and device for penem compound
US12303805B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 15, 2019 |
| Grant date | May 20, 2025 |
| Priority date | — |
| Expiry date | Aug 23, 2040 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01D2009/0086
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Provided are a continuous post-treatment method and device for a penem compound. The method includes the following steps: S1, performing continuous extraction on a reaction crude product of a penem compound, to obtain an extraction heavy phase and an extraction light phase; S2, performing continuous solid-liquid separation on the extraction heavy phase, to obtain a liquid phase separation product; S3, performing continuous pH adjustment on the liquid phase separation product until a pH value thereof is 6.1-6.3, to obtain pH-adjusted solution; and S4, performing continuous crystallization treatment on the pH-adjusted solution by a first crystallization solvent, to obtain a penem compound product. The use of the method has the advantages of high treatment speed and high efficiency, and stable material properties and a low deterioration rate during the treatment, and has better control over the yield and purity of a target product.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.