Pleuromutilin derivative containing a thiazolo[5,4-c]pyridine side chain, and a preparation method and application thereof
US12304917B1 · kind B1 · utility
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Key dates
| Filing date | Nov 18, 2024 |
| Grant date | May 20, 2025 |
| Priority date | — |
| Expiry date | Nov 18, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2603/82
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A compound of formula I, a pharmaceutically acceptable salt thereof, or a solvent compound, an enantiomer, a diastereomer or a tautomer of the compound or a pharmaceutically acceptable salt thereof is disclosed, wherein R is a phenyl substituted with an electron withdrawing group or a phenyl substituted with an electron donating group. The pleuromutilin derivative containing a thiazolo[5,4-C]pyridine side chain in the present invention exhibits good in vitro antibacterial activity and improves the problem of poor solubility of pleuromutilin derivatives.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.