Luminescent probe and its preparation method and application
US12305098B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 10, 2024 |
| Grant date | May 20, 2025 |
| Priority date | — |
| Expiry date | Jul 10, 2044 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/765
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A luminescent probe and its preparation method and application are provided. The luminescent probe has a steric hindrance group R1 of aliphatic hydrocarbon structure such as adamantane or norborneol, a detection group R2 of nitrobenzyl and its derivative structure, an electron-withdrawing group R3 containing cyano group and an electron-donating group methoxy group. In the presence of HSA or BSA, the detection group is cut off to form a parent structure that exposes atomic oxygen anions and is activated under external light irradiation, the luminescent probe can be used in solution or cells, when detecting HSA or BSA, the luminescent probe has obvious chemiluminescence characteristics, which can sensitively distinguish HSA and BSA, quantitatively analyze HSA and BSA, and determine the mixing ratio of HSA and BSA at the same time, and the luminescent probe has been successfully used for cell fluorescence imaging.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.