Polypeptide composition

US12305202B2 · kind B2 · utility

Assignees

• JECHO LABORATORIES, INC. · US
• JECHO INSTITUTE, CO., LTD. · CN

Inventors

• Jianwei Zhu · Shanghai, CN
• Jing Wang · Beijing, CN
• Lei Han · Beijing, CN
• Junsheng Chen · Beijing, CN
• Yueqing Xie · Frederick, US
• Hua Jiang · Shanghai, CN

Key dates

• Filing date: Sep 27, 2019
• Grant date: May 20, 2025
• Expiry date: Mar 9, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/55
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A polypeptide composition, and methods of making the same, may include a first polypeptide and a second polypeptide, wherein the first polypeptide comprise a first toxin fragment and a first intein fragment, the second polypeptide comprise a second toxin fragment and a second intein fragment, the first polypeptide is different from the second polypeptide; the first toxin fragment and the second toxin fragment are non-biotoxic; the first polypeptide and the second polypeptide may make the first toxin fragment and the second toxin fragment into biotoxic toxins by an interaction of the first intein fragment and the second intein fragment. Kits may include such first and second polypeptides, and such compositions and kits may be used in treating tumors.