Methods and systems for integrated on-chip single-molecule detection
US12306093B2 · kind B2 · utility
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24Claims
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Key dates
| Filing date | Oct 28, 2021 |
| Grant date | May 20, 2025 |
| Priority date | — |
| Expiry date | Jan 25, 2044 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2021/7793
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present disclosure provides methods and systems for performing single-molecule detection using fabricated integrated on-chip devices. Provided herein is a composition, comprising: (a) a substrate; (b) a structured nucleic acid particle coupled to the substrate, wherein a biological entity is coupled to the structured nucleic acid particle; and (c) a fluorescent detection agent, wherein the fluorescent detection agent comprises an affinity reagent attached to another structured nucleic acid particle, wherein the affinity reagent is bound to the biological entity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.