Biocompatible membrane composite

US12310830B2 · kind B2 · utility

Assignees

• W.L. Gore & Associates GmbH · DE
• ViaCyte, Inc. · US

Inventors

• Timothy M. Bruhn · Nonatum Mills, US
• Kevin Allen D'Amour · San Diego, US
• Christopher R. Folk · San Diego, US
• Craig McGreevy · Village of La Jolla, US
• Laura Martinson · San Diego, US
• Scott A. Ritrovato · Nonatum Mills, US
• Greg Rusch · Newark, US
• Michael Scott · San Diego, US
• Lauren Zambotti · Nonatum Mills, US
• Qiang (John) Zhang · San Diego, US
• Joseph Kakkassery · San Diego, US

Key dates

• Filing date: May 30, 2020
• Grant date: May 27, 2025
• Expiry date: Apr 24, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2420/08
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A biocompatible membrane composite including a cell impermeable layer and a mitigation layer is provided. The cell impermeable layer is impervious to vascular ingrowth and prevents cellular contact from the host. Additionally, the mitigation layer includes solid features. In at least one embodiment, mitigation layer has therein bonded solid features. In some embodiments, the cell impermeable layer and the mitigation layer are intimately bonded or otherwise connected to each other to form a composite layer having a tight/open structure. A reinforcing component may optionally be positioned external to or within the biocompatible membrane composite to provide support to and prevent distortion. The biocompatible membrane composite may be used in or to form a device for encapsulating biological entities, including, but not limited to, pancreatic lineage type cells such as pancreatic progenitors.