Selective butyrylcholinesterase inhibitor or pharmaceutically acceptable salt thereof, preparation method and use thereof

US12310944B2 · kind B2 · utility

Assignee

• CHINA PHARMACEUTICAL UNIVERSITY · CN

Inventors

• Haopeng Sun · 安丰镇, CN
• Hongyu Yang · Xi'an, CN
• Tingkai CHEN · Nanjing, CN
• Yao CHEN · Nanjing, CN
• Feng Feng · South Windsor, US
• Chenxi Du · Lo Wu, CN

Key dates

• Filing date: Sep 16, 2019
• Grant date: May 27, 2025
• Expiry date: Oct 16, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses a selective butyrylcholinesterase inhibitor having a general formula (I) or a pharmaceutically acceptable salt thereof, a preparation method and use thereof. The treatment efficacy of Alzheimer's disease, especially moderate to severe Alzheimer's disease, is tested through butyrylcholinesterase inhibitory activity, selectivity screening and toxicity to nerve cells as a carrier, and it is found that it has good target activity in vitro, extremely high selectivity and drug safety, can be used as a lead substance for further development of the treatment of Alzheimer's disease by selectively inhibiting butyrylcholinesterase.