Compositions and methods of treating ocular diseases
US12310997B2 · kind B2 · utility
0Cited by
53References
16Claims
0Family size
Assignee
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Key dates
| Filing date | Feb 10, 2023 |
| Grant date | May 27, 2025 |
| Priority date | — |
| Expiry date | Feb 10, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides recombinant adeno-associated virus (AAV) virions with altered capsid protein, where the recombinant AAV (rAAV) virions exhibit greater ability to cross barriers between intravitreal fluid and retinal cells, and thus greater infectivity of a retinal cell compared to wild-type AAV, and where the rAAV virions comprise a heterologous nucleic acid. The present disclosure provides methods of delivering a gene product to a retinal cell in an individual.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.