SK channel positive allosteric modulators

US12312333B2 · kind B2 · utility

Assignees

• Chapman University · US
• The Board of Regents of the University of Texas System · US
• Northwestern University · US

Inventors

• Miao Zhang · Orange, US
• Keykavous Parang · Irvine, US
• Naglaa Ibrahim · Orange, US
• Young Woo Nam · Orange, US
• Ilya Bezprozvanny · Austin, US
• Meng Cui · Ashburn, US

Key dates

• Filing date: Sep 29, 2022
• Grant date: May 27, 2025
• Expiry date: Sep 29, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A compound according to Formula (I) or a pharmaceutically acceptable salt thereof: is provided. X1 is N or C—Y; Y is H, halogen, NH2, OH, SH, alkyl, aryl, alkoxy, or aryloxy; A is O, NH, S, Se, or CH2, X2 is N or CH; and Z is NH, CH2, S, O, or Se.