Methods and composition involving thermophilic fibronectin type III (FN3) monobodies
US12312392B2 · kind B2 · utility
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Key dates
| Filing date | May 4, 2023 |
| Grant date | May 27, 2025 |
| Priority date | — |
| Expiry date | May 4, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The current application describes various compositions and methods for the production of FN3-based binding proteins with improved stability properties. Aspects of the disclosure relate to polypeptides comprising a variant fibronectin type III (FN3) domain from Sulfolobus tokodaii or Pyrococcus horikoshii comprising one or more amino acid substitutions or insertions in a loop region of FN3, in a non-loop region of FN3, or in both.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.