System for delivery of a payload into a cell
US12312576B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 18, 2018 |
| Grant date | May 27, 2025 |
| Priority date | — |
| Expiry date | Mar 1, 2040 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2300/0816
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system for delivering a payload to a cell that includes: a platform supporting an input container, an output container, and a receiver for receiving all or part of a disposable assembly, the disposable assembly including a preparation vessel and a constriction cartridge. The preparation vessel holds a cell suspension as it is prepared for passage through one or more cell-deforming constrictions, and the constriction cartridge houses a component that includes the one or more cell deforming constrictions. Passage through the cell-deforming constrictions causes perturbations in cell membranes to allow entry of a payload into the cells. The system includes one or more processors configured to receive input from a user and to automatically control pressure, temperature, agitation, and/or flow of the cell suspension as it passes through the input container, through the preparation vessel, through the constriction cartridge, and to the output container.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.