Method of testing crystallinity in amorphous pharmaceutical compositions
US12313613B2 · kind B2 · utility
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Key dates
| Filing date | Jan 29, 2020 |
| Grant date | May 27, 2025 |
| Priority date | — |
| Expiry date | Jun 26, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/129
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of testing pharmaceutical compositions for the presence or absence of active pharmaceutical ingredient (API) crystallinity in an amorphous solid dispersion or solid-state solution using UV/vis spectrometry is provided. Testing may be performed standalone or during manufacturing of a pharmaceutical composition. A predictive model provides for quantitative analysis of the amount of crystalline API based on UV/vis data of corresponding reference samples. Also provided is an apparatus for manufacturing a pharmaceutical composition.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.