Injectable shear-thinning hydrogel containing therapeutic agent for enhanced tumor therapy

US12318401B2 · kind B2 · utility

Assignees

• Mayo Foundation for Medical Education and Research · US
• The Regents of the University of California · US
• Boston Scientific Scimed, Inc. · US

Inventors

• Hanjun Kim · Seoul, KR
• Chun Xu · Los Angeles, US
• Ehsan Jabbarzadeh · Columbia, US
• Rahmi Oklu · Scottsdale, US
• Alireza Khademhosseini · Cambridge, US

Key dates

• Filing date: Sep 29, 2022
• Grant date: Jun 3, 2025
• Expiry date: Sep 29, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2389/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

We have developed novel shear-thinning biomaterials using silica nanoparticles, gelatin-based polymers and small molecules such as doxorubicin. Shear-thinning biomaterial technology offers enables polymers and drugs loaded inside such polymers to be easily delivered directly through catheters into target area for use, for example, in cancer therapy and immunotherapy. When a force above a certain threshold is applied to inject such materials, they “thin” and behaves as a semi-solid, allowing the material to readily flow through a catheter. When the force is removed, the material instantly becomes a soft solid with significant cohesive properties that prevent it from dislodging or breaking up.