Attenuating viral mutations in protein genes

US12318439B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jaclyn Kaiser · Galveston, US
• Tian Wang · Galveston, US
• Alan Barrett · Galveston, US
• Kassandra Carpio · Galveston, US

Key dates

• Filing date: May 5, 2022
• Grant date: Jun 3, 2025
• Expiry date: Sep 30, 2042

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments relate to attenuated flaviviruses for use in vaccines and immunogenic compositions. Embodiments include methods for treating or preventing one or more conditions, for example flavivirus infection, using an attenuated flavivirus. In some embodiments, the provided methods and compositions involve one or more attenuated flaviviruses that are capable of inducing a protective immune response.