Therapeutic nanoparticles containing argonaute for microRNA delivery and compositions and methods using same
US12318456B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Mar 10, 2018 |
| Grant date | Jun 3, 2025 |
| Priority date | — |
| Expiry date | Oct 11, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2320/32
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to oligonucleotide carriers for oligonucleotide delivery to a subject to provide gene therapy. More particularly, the present invention relates to therapeutic nanoparticles for microRNA (miRNA) delivery to a subject. More particularly, the present invention relates to therapeutic nanoparticles wherein miRNA is bindable to biocompatible nanoparticles using natural gene carrier Argonaute (AGO) protein or a variant thereof. Optionally, therapeutic nanoparticles of the present invention additionally contain targeting moieties for targeting therapeutic nanoparticles to cancer cells and/or chemotherapeutic agents. Optionally, biocompatible nanoparticles are trackable nanoparticles, such as superparamagnetic iron oxide nanoparticles (SPION), to provide multifunctional theranostics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.