Use of mutant of immunoglobulin degrading enzyme IdeE
US12319942B2 · kind B2 · utility
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Key dates
| Filing date | Jun 21, 2024 |
| Grant date | Jun 3, 2025 |
| Priority date | — |
| Expiry date | Jun 21, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12R2001/46
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a mutant of an immunoglobulin degrading enzyme IdeE, a protein comprising the mutant, and a use of a composition and a kit in preparation of a drug for reducing the level of IgG in a subject. The mutant has amino acid substitution, N-terminal truncated and/or C-terminal truncated on one or more of positions 8, 10, 24, 59, 97, and 280 of the amino acid sequence shown in SEQ ID NO: 2, and the mutant has the function of the immunoglobulin degrading enzyme IdeE, and has higher activity and thermal stability than wild-type IdeE.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.