5-(4-pyridyloxy)pyrazole compounds serving as TGF-βR1 kinase inhibitor

US12325695B2 · kind B2 · utility

Assignee

• JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. · CN

Inventors

• Xiangyu FU · Shanghai, CN
• Charles Z. Ding · San Mateo, US
• Lihong Hu · Shanghai, CN
• Shuhui CHEN · Shanghai, CN

Key dates

• Filing date: Jan 22, 2020
• Grant date: Jun 10, 2025
• Expiry date: Aug 8, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are a group of 5-(4-pyridyloxy)pyrazole compounds serving as a TGF-βR1 kinase inhibitor, and applications of same in preparing a TGF-βR1 kinase inhibitor medicament. Specifically disclosed are the compounds as represented by formula (I), a pharmaceutically acceptable salt or an isomer thereof.