Ectonucleotide pyrophosphatase-phosphodiesterase-1 (ENPP1) inhibitors and uses thereof

US12325720B2 · kind B2 · utility

Assignee

• 1cBio, Inc. · US

Inventors

• Brahmam Pujala · Greater Noida, IN
• Amantullah Ansari · Noida, IN
• Shreya Sapra · Greater Noida, IN
• Pradeep S. Jadhavar · Noida, IN
• Dhananjay Pendharkar · Noida, IN
• Sreekanth A. Ramachandran · Noida, IN
• Uzma Saeed · New Delhi, IN
• Abhinandan Danodia · Greater Noida, IN
• Farha Khan · New Delhi, IN
• Sagar Patni · Noida, IN
• Sanjeev Soni · Noida, IN
• Ashu Gupta · Noida, IN
• Sarvajit Chakravarty · Sunnyvale, US
• Balaji Dashrath Sathe · Greater Noida, IN

Key dates

• Filing date: Jun 13, 2024
• Grant date: Jun 10, 2025
• Expiry date: Jun 13, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/65583
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention discloses compounds useful in treatment of conditions associated with dysfunction of ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) enzyme. Specifically, the present invention discloses compound of formula (J) which exhibit inhibitory activity against ENPP1. Method of treating conditions associated with over-expression of ENPP1 gene with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.