Immunoglobulin proteins that bind to NPR1 agonists
US12325752B2 · kind B2 · utility
0Cited by
7References
44Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 17, 2021 |
| Grant date | Jun 10, 2025 |
| Priority date | — |
| Expiry date | Dec 17, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides novel immunoglobulin proteins that bind to a human natriuretic peptide receptor 1 (NPR1) agonist, preferably an anti-NPR1 antibody. In certain embodiments, the proteins of the disclosure comprise at least one immunoglobulin variable domain that binds to an anti-NPR1 antibody. In certain embodiments, the proteins of the disclosure are useful in blocking and/or reversing the effect of an administered anti-NPR1 antibody. In certain embodiments, the antigen-binding proteins are useful for effective management of blood pressure and hemodynamics in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.