Recombinant virus products and methods for inhibition of expression of myotilin
US12325856B2 · kind B2 · utility
0Cited by
7References
10Claims
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Key dates
| Filing date | Jul 13, 2021 |
| Grant date | Jun 10, 2025 |
| Priority date | — |
| Expiry date | May 8, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to RNA interference-based methods for inhibiting the expression of the myotilin gene. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of myotilin. The methods have application in the treatment of muscular dystrophies such as Limb Girdle Muscular Dystrophy Type 1A.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.