MDA-7/IL-24 secretory variants and methods of use

US12325863B2 · kind B2 · utility

Assignee

• Virginia Commonwealth University · US

Inventors

• Paul Fisher · Scarsdale, US
• Mitchell E. Menezes · Richmond, US
• Praveen Bhoopathi · Richmond, US
• Swadesh K. Das · Richmond, US
• Luni Emdad · Richmond, US
• Devanand Sarkar · Richmond, US
• Anjan K. Pradhan · Richmond, US
• Xiang-Yang Wang · Buffalo, US

Key dates

• Filing date: Jan 23, 2019
• Grant date: Jun 10, 2025
• Expiry date: Oct 13, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/10343
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

In various aspects, the present disclosure provides polynucleotides encoding a fusion protein, as well as vectors, cells, and compositions comprising the same. In embodiments, the fusion protein includes an insulin signal peptide and an MDA-7/IL-24 protein. Methods of using the polynucleotides, vectors, cells, and compositions, such as in the treatment or prevention of cancer, are also provided.