Preparation method and application of nanobody targeting dengue virus NS1 protein
US12326452B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 21, 2024 |
| Grant date | Jun 10, 2025 |
| Priority date | — |
| Expiry date | Nov 21, 2044 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/185
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are a preparation method and application of a nanobody targeting dengue virus NS1 protein. The nanobody targeting dengue virus NS1 protein is a VHH antibody, which is obtained by constructing a nanobody phage library through phage screening technology, and has an amino acid sequence shown in SEQ ID NO: 1. The nanobody in the present disclosure exhibits high affinity and specificity when being bound to the dengue virus NS1 protein, and has advantages of good stability and low cost compared with monoclonal antibodies. Therefore, the nanobody in the present disclosure can be produced on a large scale, and has bright application prospects in the field of dengue virus detection and analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.