Compounds suitable for the treatment and prophylaxis of muscle wasting and other conditions

US12331042B2 · kind B2 · utility

Inventors

• Volker Adams · Leipzig, DE
• Siegfried Labeit · Neckargemünd, DE

Key dates

• Filing date: Aug 14, 2020
• Grant date: Jun 17, 2025
• Expiry date: Jul 17, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D411/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a compound of the general formula I and the pharmaceutically acceptable salts thereof; where the variables are as defined in the claims and the description. The invention also relates to the compounds of formula I for use in the treatment or prophylaxis of muscle wasting conditions, of skeletal or cardial muscle atrophy, of conditions, in particular of myopathies, which are associated with an increased Muscle RING Finger 1 (MuRF1) expression and of other conditions; to the compounds of formula I for use as a medicament; to a pharmaceutical composition comprising at least one compound of formula I and to a method for treating said conditions.