Multispecific polypeptide constructs having constrained CD3 binding and related methods and uses
US12331132B2 · kind B2 · utility
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21Claims
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Key dates
| Filing date | Jun 6, 2023 |
| Grant date | Jun 17, 2025 |
| Priority date | — |
| Expiry date | Jun 6, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, components of the multispecific polypeptides are connected by a non-cleavable linker. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.