Patent · US Active

T cell which expresses a gamma-delta t cell receptor (TCR) and a chimeric antigen receptor (CAR)

US12331316B2 · kind B2 · utility

0Cited by

2References

10Claims

0Family size

Assignee

UCL Business Ltd · GB

Inventors

John Anderson · London, GB
Jonathan Fisher · Acton, US
Martin Pulé · London, GB
Kenth Gustafsson · London, GB

Key dates

Filing date	Nov 17, 2021
Grant date	Jun 17, 2025
Priority date	—
Expiry date	May 12, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2510/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a T cell which expresses a gamma-delta T cell receptor (TCR) and a chimeric antigen receptor (CAR), wherein the CAR comprises: an antigen binding domain; a transmembrane domain; and a co-stimulatory intracellular signalling domain; wherein the intracellular signalling domain provides a co-stimulatory signal to the T cell following binding of antigen to the antigen binding domain.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.