Colorimetric sensing with reconfigurable chiral plasmonic structures and a method for detecting analytes in samples using the same
US12332240B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 21, 2022 |
| Grant date | Jun 17, 2025 |
| Priority date | — |
| Expiry date | Dec 21, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/54386
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention is directed to a nanoscaled construct, said construct comprising or essentially consisting of a nucleic acid structure with reconfigurable or switchable features, and at least two separate metallic nanoparticles coupled with said nucleic acid structure, wherein said two separate nanoparticles are at an interchangeable angle to each other, wherein said nanoparticles provide high chirality and/or optical activity within the visible and near-infrared (NIR) spectrum from 400 to 800 nm generating a color for the construct, and wherein said construct has an absorption dissymmetry factor (g-factor) of over 10%. There is also provided a method for detecting an analyte in a sample, the method comprising steps of contacting a nanoscaled construct of the present disclosure specific to said analyte with a sample in a test assay, and detecting said analyte in said sample by optical means or by naked eye, wherein the presence of the analyte in said sample changes the color of said nanoscaled structure and the change of color in said assay confirms the presence of the analyte in said sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.