Identifying the vascularity of cerebral tissue in subjects using deoxyhemoglobin contrast
US12336783B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 29, 2022 |
| Grant date | Jun 24, 2025 |
| Priority date | — |
| Expiry date | Sep 29, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61M2230/30
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Deoxyhemoglobin contrast has been used to locate arteries based on the earlier blood oxygen-level dependent (BOLD) signal arrival time, higher BOLD signal strength, and shorter mean transit time. However, additional strategies of identifying arteries with oxygen modulation are required to improve the sensitivity and specificity of results. The present disclosure provides a method of distinguishing extravascular voxels from intravascular voxels based on the magnetic signal obtained from two hypoxic boluses having two different baselines. Intravascular voxels are responsive to changes in the baseline due to their high blood volume, while extravascular voxels are not affected by changes to the baseline. Amongst intravascular voxels, arteries can be distinguished from veins because the extraction fraction of the arterial blood is reduced during hypoxia, and therefore veins are less sensitive to changes in the baseline.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.