Conjugates comprising cleavable beta-glucuronide-containing linkers

US12337038B2 · kind B2 · utility

Inventors

• Akbar Husain Khan · Waltham, US
• Andreas Maderna · Stony Point, US
• Maximillian Taro William Lee · London, GB
• Mattia COCCO · London, GB
• Boliang Deng · Waltham, US
• Jonathan David BEADLE · London, GB
• Albano GALAN COCA · London, GB
• Alla Pryyma · Waltham, US
• Nicole Danielle Bartolo · Waltham, US
• Luke Masterson · Cambridge, GB
• William Robert Fraser Goundry · Cambridge, GB

Key dates

• Filing date: Apr 9, 2024
• Grant date: Jun 24, 2025
• Expiry date: Apr 9, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/203
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The specification relates to conjugates comprising a linker of Formula (IA): and pharmaceutically acceptable salts thereof. The specification also relates the use of the conjugates for the treatment of diseases such as cancer, and intermediates useful for the synthesis of the conjugates.