Inhibitors of SARM1
US12338238B2 · kind B2 · utility
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19References
16Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 6, 2019 |
| Grant date | Jun 24, 2025 |
| Priority date | — |
| Expiry date | Oct 16, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/74
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.