Antibody variant combinations and uses thereof
US12338289B2 · kind B2 · utility
0Cited by
7References
17Claims
0Family size
Assignee
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Key dates
| Filing date | May 3, 2019 |
| Grant date | Jun 24, 2025 |
| Priority date | — |
| Expiry date | Oct 27, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are combinations of first and second antibodies having modified Fc effector functions resulting from amino acid substitutions in the Fc region, the amino acid substitutions allow for co-dependent activation of effector functions such as CDC and/or ADCC. Also provided are combinations of first and second antibodies having agonistic activity or enhanced agonistic activity resulting from amino acid substitutions in the Fc region where the agonistic activity is co-dependent of both a first and second antibodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.