Method for correcting motion artifacts of in vivo fluorescence measurements
US12339431B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 23, 2021 |
| Grant date | Jun 24, 2025 |
| Priority date | — |
| Expiry date | Sep 3, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30241
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for correcting motion artifacts of in vivo fluorescence measurements using a 3D laser scanning microscope containing two pairs of orthogonally arranged acousto-optic deflectors, the method including: selecting a region of interest; selecting a plurality of guiding points along the region of interest; extending the guiding points to objects selected from scanning lines and/or surface elements and/or volume elements which, together, substantially cover the region of interest; repeatedly scanning the objects by generating continuous drifts to cover the objects; projecting the obtained scanning data to frames and obtaining a time series of the frames; correcting motion artifacts by shifting the data of the successive frames with respect to each other so as to maximize fluorescence cross correlation between the data of the frames.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.