Artificial neural network models for prediction of de novo sequencing of chains of amino acids
US12340874B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 25, 2018 |
| Grant date | Jun 24, 2025 |
| Priority date | — |
| Expiry date | Mar 12, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/20
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present invention relates to proteomics, and techniques for predicting de novo sequencing of chains of amino acids, such as peptides, proteins, or combinations thereof. Particularly, aspects of the present invention are directed to a computer implemented method that includes obtaining a digital representation of a mass spectrum, the digital representation including a plurality of container elements, encoding, using an encoder portion of a bidirectional recurrent neural network of long short term memory cells and gated recurrent unit cells, each container element as an encoded vector, decoding, using a decoder portion of the bidirectional recurrent neural network, each of the encoded vectors into a sequence of amino acids; and recording the sequence of amino acids as a multi-dimensional data set of amino acids types and a probability of each of the amino acid types in each position of the complete amino acid sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.