Systems and methods for determining lesion depth using fluorescence imaging

US12343114B2 · kind B2 · utility

Assignees

• The George Washington University · US
• 460Medical, Inc. · US

Inventors

• Marco A. Mercader · Arlington, US
• Narine Sarvazyan · Potomac, US
• Terrance Ransbury · Chapel Hill, US
• Kenneth C. Armstrong · Cary, US
• Omar Amirana · Palo Alto, US

Key dates

• Filing date: Jul 29, 2021
• Grant date: Jul 1, 2025
• Expiry date: Jul 29, 2041

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B2576/023
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Systems, catheter and methods for treating Atrial Fibrillation (AF) are provided, which are configure to illuminate a heart tissue having a lesion site; obtain a mitochondrial nicotinamide adenine dinucleotide hydrogen (NADH) fluorescence intensity from the illuminated heart tissue along a first line across the lesion site; create a 2-dimensional (2D) map of the depth of the lesion site along the first line based on the NADH fluorescence intensity; and determine a depth of the lesion site at a selected point along the first line from the 2D map, wherein a lower NADH fluorescence intensity corresponds to a greater depth in the lesion site and a higher NADH fluorescence intensity corresponds to an unablated tissue. The process may be repeated to create a 3 dimensional map of the depth of the lesion.