Method of delivery of DNA or RNA cargo unshielded lipid nanoparticles and compositions thereof
US12343429B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 4, 2024 |
| Grant date | Jul 1, 2025 |
| Priority date | — |
| Expiry date | Oct 4, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present disclosure provides unshielded lipid nanoparticles and a process that enables the production of such unshielded lipid nanoparticles, thereby overcoming previous challenges of making particles without causing aggregation thereof. The lipid nanoparticles comprise a nucleic acid cargo molecule; a sterol or a derivative thereof present at a content of at least 12 mol %; a neutral lipid, such as a phospholipid having a choline head group present at a content of between 22 mol % and 65 mol %; and an ionizable cationic amino lipid present at a content of between 15 mol % and 45 mol %; wherein the lipid nanoparticle is non-sterically stabilized with a hydrophilic polymer-lipid conjugate, or otherwise unshielded and wherein each mol % content is relative to total lipid present in the lipid nanoparticle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.