Anionic exchange-hydrophobic mixed mode chromatography resin
US12343702B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 8, 2019 |
| Grant date | Jul 1, 2025 |
| Priority date | — |
| Expiry date | Apr 14, 2042 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J2220/52
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
Chromatography resins having anionic exchange-hydrophobic mixed mode ligands, that are useful for purifying target biomolecules using anionic exchange (i.e., where the ligand is positively charged) and hydrophobic mixed mode chromatography. The chromatography resins allow for efficient purification of target biomolecules (e.g., recombinant proteins, antibodies, antibody-drug conjugates, or antibody derivatives including, but not limited to, antibody fragments and antibody fusions) from a sample, and have been found to be useful in purifying monomeric target biomolecules from aggregate target biomolecules. In an embodiment, the chromatography resins are useful for separating antibodies from one or more components (e.g., contaminants) in the sample.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.