Patent · US Active

Functionalized UBX protein materials for enhanced purification of antibodies

US12344638B2 · kind B2 · utility

0Cited by
0References
9Claims
0Family size

Assignee

Inventors

Key dates

Filing dateApr 2, 2020
Grant dateJul 1, 2025
Priority date—
Expiry dateDec 27, 2041

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2319/705
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

Provided herein are methods and compositions for purifying antibodies. Purification is achieved by increasing the binding capacity of protein A chromatography by covalent attachment of a protein A domain (E, D, A, B, C), or domain Z, or a functional variant thereof, to Drosophila melanogaster transcription factor Ultrabithorax (Ubx) materials. The compositions include fusion proteins containing Drosophila melanogaster transcription factor Ultrabithorax (Ubx) or a fragment thereof and an immunoglobulin binding protein. In some embodiments, the immunoglobulin binding protein is a protein A domain, a protein Z domain or a fragment thereof.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.