bZIP transcription factors regulate conversion of nicotine to nornicotine and reduce levels of tobacco specific (TSNA) precursors
US12344853B2 · kind B2 · utility
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40Claims
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Key dates
| Filing date | Jun 5, 2020 |
| Grant date | Jul 1, 2025 |
| Priority date | — |
| Expiry date | Jan 24, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA24B3/08
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of decreasing conversion of nicotine to nornicotine is provided herein. The methods includes administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof. Also provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a bZIP type transcription factor binding site on a promoter of a nicotine N-demethylase (NND). Further provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a plant genome to knockout at least one bZIP type transcription factor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.