Inducing caspase activity

US12350288B2 · kind B2 · utility

Assignee

• DOW GLOBAL TECHNOLOGIES LLC · US

Inventors

• Caroline Woelfle-Gupta · Midland, US
• Andrew Scott · Melbourne, AU
• Matthew LeBaron · Midland, US
• Daniel Wilson · Midland, US
• Susan L. Jordan · Doylestown, US
• Robert L. Schmitt · Stuart, US
• Raja Settivari · Midland, US

Key dates

• Filing date: Feb 26, 2020
• Grant date: Jul 8, 2025
• Expiry date: May 23, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Embodiments are directed towards methods of inducing caspase activity. The methods include contacting a cell with a treatment compound represented by the following Formula (I): where R1 is selected from hydrogen or an alkyl group having from 1 to about 16 carbon atoms; R2 is selected from a hydroxyl group, a tosylate group, an alkoxy group of the formula OR3 where R3 is selected from an alkyl group having from 1 to about 16 carbon atoms, or an ester group of the formula OCOR4, where R4 is an alkyl group having from 1 to about 16 carbon atoms, and n is from 4 to 46,000, with the proviso that when R1 is hydrogen and R2 is a hydroxy group the treatment compound has a number average molecular weight from 10,100 to 2,000,0000 g/mol.